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Why I Start with Gut Testing: How Your Gut Affects Every System of Your Body

The gut plays a crucial role in influencing every system throughout your body. Here's a closer look at some key ways in which your gut affects your overall well-being:


The digestive tract is arguably the leading cause of inflammation in your body. When your gut is inflamed, it can cause inflammation throughout your entire body. Here's a closer look at how gut inflammation can manifest in different symptoms:

  • Fatigue - Chronic inflammation in the gut can lead to systemic fatigue, leaving you feeling constantly tired and drained of energy, often this can be related to creating an imbalance in your stress hormone cortisol. This fatigue may persist even after sufficient rest, significantly impacting your daily activities and overall quality of life. Some often call this adrenal fatigue or chronic fatigue syndrome. 

  • Depression and anxiety - The gut-brain connection is a well-established phenomenon, with the gut often referred to as the "second brain." Inflammation in the gut can disrupt this intricate relationship, potentially contributing to the development or exacerbation of mood disorders such as depression and anxiety. Research suggests that inflammation can alter neurotransmitter function and communication between the gut and brain, influencing mood and emotional well-being.

  • Brain fog -  An all too common symptom I get in my office is brain fog. Inflammation-induced cognitive impairment, commonly known as brain fog, can make it challenging to concentrate, think clearly, and retain information. This cognitive cloudiness may interfere with work, school, or daily tasks, affecting productivity and cognitive function.

  • Insomnia - Gut inflammation can disrupt the delicate balance of neurotransmitters and hormones involved in regulating sleep-wake cycles. As a result, you may experience difficulty falling asleep, staying asleep, or achieving restorative sleep, leading to insomnia and daytime fatigue. 

  • Acne and other skin issues - Inflammation in the gut can contribute to systemic inflammation, which may manifest as skin conditions such as acne, eczema, or psoriasis. Imbalances in gut microbiota and increased intestinal permeability (leaky gut) can trigger immune responses that exacerbate skin inflammation and disrupt skin health.

  • Female hormone imbalances - Gut inflammation can disrupt hormone balance in women, potentially leading to irregular menstrual cycles, PMS symptoms, or exacerbation of conditions like polycystic ovary syndrome (PCOS) or endometriosis. Hormonal imbalances can also contribute to mood swings, fatigue, and other symptoms associated with gut-related inflammation.

  • Male hormone imbalances - Similarly, gut inflammation can affect hormone levels in men, leading to imbalances in testosterone, estrogen, or other hormones. These imbalances may manifest as decreased libido, erectile dysfunction, mood changes, or disruptions in energy levels and overall vitality.

  • Hypothyroid symptoms - Inflammation in the gut can contribute to disruptions in thyroid function, potentially exacerbating symptoms of hypothyroidism. These symptoms may include fatigue, weight gain, dry skin, hair loss, cold intolerance, and cognitive impairment, among others.

Nutrient Absorption

Although you might be eating a healthy diet, if you are not absorbing those nutrients, it’s almost like you’re not eating or you're eating a SAD diet (Standard American Diet). This is known as malabsorption and can have major impacts on our health and well being. 

Here are some ways nutrient absorption can show up in our bodies and how it relates to gut health:

  • Sluggish metabolism - Nutrient imbalances and deficiencies can disrupt metabolic processes, including energy metabolism, hormone regulation, and cellular function, leading to a sluggish metabolism and difficulty maintaining a healthy weight. This can often show up as high cholesterol, high blood sugar and an inability to lose weight. 

  • Persistent Fatigue - Deficiencies in energy-producing nutrients such as B vitamins, magnesium, and iron can result in chronic fatigue, weakness, and reduced stamina.

  • Nutrient Deficiencies - Malabsorption often leads to deficiencies in key vitamins and minerals, such as vitamin B12, vitamin D, iron, calcium, and magnesium. These deficiencies can have widespread effects on various bodily functions and may increase the risk of developing health conditions.

  • Dry or Thinning Hair -  Inadequate intake of essential nutrients like vitamins A, C, D, E, biotin, and minerals such as iron and zinc can contribute to hair issues, including dryness, brittleness, and hair loss.

  • Cravings - Nutrient deficiencies may trigger cravings for specific foods as the body seeks to obtain the nutrients it lacks. These cravings can lead to unhealthy eating habits and further exacerbate nutrient imbalances.

  • Aging Skin - Nutrient deficiencies, particularly in vitamins A, C, and E, as well as essential fatty acids, can impair skin health, leading to premature aging, dryness, wrinkles, and decreased elasticity.

Immune Dysregulation and Autoimmunity

The greatest amount of immune cells in your entire body are found in your small intestine. When there are issues in the small intestine, like bacterial overgrowths, fungal overgrowths, or inflammation, they have a significant impact on our immune system. This unique feature is essential for the gut's role in immune function and defense against pathogens. Here are some examples of what these immune systems can look like in everyday life: 

  • Hypothyroidism/Hashimoto's -  Intestinal permeability, commonly known as leaky gut, can allow undigested food particles and toxins to enter the bloodstream, triggering an immune response. This immune activation can lead to the production of antibodies that may cross-react with thyroid tissue, contributing to the development or exacerbation of Hashimoto's thyroiditis, a common cause of hypothyroidism.

  • Joint Pain/Rheumatoid Arthritis - Research demonstrates gut dysbiosis and intestinal permeability plays a role in the development and progression of rheumatoid arthritis (RA), an autoimmune disorder characterized by chronic inflammation of the joints. Dysregulated immune responses in the gut can contribute to systemic inflammation and autoimmunity, potentially exacerbating joint inflammation in RA.

  • Celiac Disease and Gluten Intolerance - Both can occur because of immune dysregulation in the small intestine. Celiac disease is an autoimmune disorder characterized by an abnormal immune response to gluten, a protein found in wheat, barley, and rye. In individuals with celiac disease, gluten consumption triggers inflammation and damage to the lining of the small intestine, leading to malabsorption of nutrients and systemic immune activation. 

  • Irritable Bowel Syndrome (IBS) - Research shows that IBS is due to an overactive immune response in the gut. Gut dysbiosis, inflammation, and altered gut-brain communication are common features of the disorder. Small intestinal bacterial overgrowth (SIBO) and other gut-related issues can contribute to IBS symptoms such as abdominal pain, bloating, diarrhea, and constipation.

  • Food Sensitivities - Food sensitivities and intolerances can arise from immune-mediated reactions to specific dietary antigens, leading to inflammation and gastrointestinal symptoms. Small intestinal permeability and dysbiosis may contribute to heightened immune reactivity and increased susceptibility to food-induced immune responses.

  • Inflammatory Bowel Disease (IBD) - Inflammatory bowel diseases, including Crohn's disease and ulcerative colitis, are autoimmune conditions characterized by chronic inflammation of the gastrointestinal tract. Dysregulated immune responses in the gut, genetic predisposition, and environmental factors contribute to the development and progression of IBD.

These are just a few examples to illustrate how issues in the small intestine, such as dysbiosis, SIBO, inflammation, and gut permeability, can contribute to various autoimmune conditions and immune responses. There are others. 

It is now known that the human body contains more bacterial cells than human cells, and that all of these bacteria are important for health and well being. Addressing gut inflammation is crucial for mitigating these symptoms and promoting optimal health and well-being. Implementing strategies to support gut health, such as dietary modifications, stress management, probiotics, and targeted supplements, can help reduce inflammation and restore balance within the digestive tract, ultimately alleviating symptoms and improving overall quality of life.


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