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The Vital Importance of Vitamin B12: A Key Player in Health and Wellness

Updated: Mar 27

In the realm of health and wellness, there's a common thread that connects a wide range of seemingly disparate conditions:

  • Alzheimer's, dementia, cognitive decline, memory loss

  • Multiple sclerosis or other neurological disorders

  • Mental illness - depression, anxiety, bipolar, psychosis

  • Cardiovascular disease

  • Learning or developmental disorders

  • Autism spectrum disorders

  • Autoimmune disease and immune dysregulation

  • Cancer

  • Male and female infertility

That common thread is a deficiency of a vital nutrient – Vitamin B12.



In this blog post, I will explain the significance of Vitamin B12, its role in various bodily functions, the factors contributing to its deficiency, and practical steps to address this critical issue.


Understanding Vitamin B12

  • Vitamin B12, also known as cobalamin, is an essential water-soluble vitamin that works together with folate (B9) to synthesize neurotransmitters and maintain the myelin sheath surrounding nerve cells. This integral function supports optimal brain and neurological function.

  • Additionally, Vitamin B12 aids in the production of white blood cells, which are crucial for a robust immune system and helps us fight infections.

  • B12 regulates homocysteine levels - elevated homocysteine levels are associated with cardiovascular disease and brain issues. In order to safeguard against these cardiovascular and neurological problems, we need to keep our B12 and folate levels at optimal amounts.

  • B12 is also a key player in red blood cell formation, preventing the development of macrocytic anemia, where red blood cells are abnormally large.


The Prevalence of B12 Deficiency

  • Data from the Tufts University Framingham Offspring Study suggests that a startling 40 percent of individuals aged 26 to 83 have plasma B12 levels within the low-normal range, often accompanied by neurological symptoms.


Why is B12 deficiency so rampant?

  • The answer lies in the complexity of B12 absorption, which involves multiple stages. Various factors contribute to B12 malabsorption, low stomach acid, including medication use, intestinal dysbiosis, gut inflammation, leaky gut, aging, atrophic gastritis, alcohol consumption, and pernicious anemia – an autoimmune condition.


High-Risk Groups >>> Certain groups are particularly vulnerable to B12 deficiency:


1. Vegetarians and Vegans: Since B12 is exclusively found in animal products, plant-based diets lack this crucial nutrient. Studies show that 50% of vegetarians and a staggering 80% of vegans are deficient in B12.


2. Medication Users: Those taking medications like PPIs, acid-suppressing drugs, statins, metformin, birth control pills, and certain antidepressants are at a heightened risk of B12 depletion.


3. Individuals with Gut Issues: Gut health plays a pivotal role in nutrient absorption. Those with gut problems are more susceptible to B12 deficiency. Low stomach acid can contribute to this issue as well as dysbiosis (which is an imbalance in the microbiome of beneficial bacteria to pathogens).


Identifying B12 Deficiency


B12 deficiency progresses through four stages:


1. Stages I and II: Plasma B12 stores deplete, and holotranscobalamin levels drop.

2. Stage III: Homocysteine levels rise, and MMA concentrations increase in urine and blood.

3. Stage IV: Clinical signs become apparent, including macrocytic anemia and symptoms like peripheral neuropathy and brain fog.


Symptoms Associated with B12 deficiency

  • Memory problems

  • Fatigue

  • Thinning hair

  • Anemia

  • Hormone imbalance

  • Heart disease

  • Chronic pain and headaches

  • Infertility

  • Tingling in the arms, legs, fingers


Taking Action


If you suspect a B12 deficiency, taking action is crucial:


1. Get Tested: Consult a healthcare professional for proper testing and diagnosis. Most often this is not tested in a conventional setting, so finding a Functional Provider is usually needed.


2. Dietary Changes: Incorporate B12-rich foods into your diet, such as beef, lamb, cheese, eggs, seafood, and shellfish.


3. Supplementation: Opt for methylcobalamin over cyanocobalamin, as it has superior absorption and can cross the blood-brain barrier. Co-factors like B9, B6, and magnesium enhance B12 absorption.


Final Notes


Vitamin B12 plays a foundational role in overall health and well-being, impacting brain function, immune response, and red blood cell formation. Given its prevalence in various health conditions, recognizing and addressing B12 deficiency is of paramount importance. Whether through dietary adjustments or supplementation, taking steps to maintain adequate B12 levels can contribute to a healthier, more vibrant life. Remember, your health matters, and seeking professional guidance is a proactive step toward optimal wellness.



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